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Quantum Biology: The Hidden Nature of Nature
 
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Can the spooky world of quantum physics explain bird navigation, photosynthesis and even our delicate sense of smell? Clues are mounting that the rules governing the subatomic realm may play an unexpectedly pivotal role in the visible world. Join leading thinkers in the emerging field of quantum biology as they explore the hidden hand of quantum physics in everyday life and discuss how these insights may one day revolutionize thinking on everything from the energy crisis to quantum computers. The World Science Festival gathers great minds in science and the arts to produce live and digital content that allows a broad general audience to engage with scientific discoveries. Our mission is to cultivate a general public informed by science, inspired by its wonder, convinced of its value, and prepared to engage with its implications for the future. Subscribe to our YouTube Channel for all the latest from WSF. Visit our Website: http://www.worldsciencefestival.com/ Like us on Facebook: https://www.facebook.com/worldsciencefestival Follow us on twitter: https://twitter.com/WorldSciFest Original Program Date: June 1, 2012 MODERATOR: John Hockenberry PARTICIPANTS: Paul Davies, Seth Lloyd, Thorsten Ritz John Hockenberry's introduction 00:13 Participant Introductions 06:28 How is there a convergence between biology and the quantum? 7:45 Are particles in two places at once or is this based just on observations? 12:43 Are biological states creating a unique quantum rules? 17:32 Quantum mechanics is so counterintuitive. 23:00 Can nature have a quantum sense? 27:29 The quantum migration of birds... With bird brains? 31:50 Electron spin and magnetic fields. 37:00 Cryptochrome releases particles with spin and the bird knows where to go. 40:28 How is bird migration an example for evolution? 49:13 photosynthesis and quantum phenomena. 55:00 Bacteria doing quantum search. 1:00:21 Is quantum tunneling the key to quantum biology? 1:06:56 What are the experiments that prove this? 1:12:28 When fields converge how do you determine causality? 1:19:49 We have no idea how life began. 1:24:59 Replication leads to variation which is the beginning of life? 1:31:05
Views: 499992 World Science Festival
Joseph Takahashi (UT Southwestern/HHMI) Part 1A: Circadian Clocks: Clock Genes, Cells and Circuits
 
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https://www.ibiology.org/genetics-and-gene-regulation/circadian-clocks/ Lecture Overview: Circadian rhythms are an adaptation to the 24 hr day that we experience. Takahashi begins his talk with an historic overview of how the genes controlling circadian clocks were first identified in Drosophila and the cloning tour de force that was required to identify clock genes in mice. He also describes the experiments that resulted in the realization that all cells in the body have a circadian clock, not just cells in the brain. In part 1B, Takahashi explains that the suprachiasmatic nucleus (SCN) in the brain generates a circadian rhythm of fluctuating body temperature that, in turn, signals to peripheral tissues. Heat shock factor 1 is one of the signaling molecules responsible for communicating the temperature information and resetting peripheral clocks. In Part 2, Takahashi describes how crossing many mice of different genetic backgrounds allowed his lab to identify several genes that impact the output of the clock gene system through different mechanisms. Takahashi begins the last part of his presentation with the crystal structures of BMAL and Clock, the two central activators of clock gene transcription. He goes on to describe how his lab showed that BMAL/Clock controls the DNA binding activity of transcriptional regulators of not only cycling genes, but also of basic cell functions such as RNA polymerase 2 occupancy and histone modification. Speaker Bio: Joseph Takahashi received his BA in biology from Swarthmore College, his PhD in neuroscience from the University of Oregon, and he was a post-doctoral fellow with Martin Zatz at the National Institutes of Mental Health. He then spent 26 years at Northwestern University where he was a faculty member in the Department of Neurobiology and Physiology and in 1997 he became an Investigator of the Howard Hughes Medical Institute. In 2008, Takahashi joined the University of Texas, Southwestern Medical Center as the Loyd B. Sands Distinguished Chair in Neuroscience. Using forward genetic screens in mice, Takahashi identified the first mammalian circadian gene "Clock" in 1997. Since then, his lab has gone on to identify and clone numerous circadian genes in both the brain and tissues throughout the body. Takahashi has received numerous awards and honors for his ground-breaking research including election to the National Academy of Sciences.
Views: 15708 iBiology
How Quantum Biology Might Explain Life’s Biggest Questions | Jim Al-Khalili | TED Talks
 
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How does a robin know to fly south? The answer might be weirder than you think: Quantum physics may be involved. Jim Al-Khalili rounds up the extremely new, extremely strange world of quantum biology, where something Einstein once called “spooky action at a distance” helps birds navigate, and quantum effects might explain the origin of life itself. TEDTalks is a daily video podcast of the best talks and performances from the TED Conference, where the world's leading thinkers and doers give the talk of their lives in 18 minutes (or less). Look for talks on Technology, Entertainment and Design -- plus science, business, global issues, the arts and much more. Find closed captions and translated subtitles in many languages at http://www.ted.com/translate Follow TED news on Twitter: http://www.twitter.com/tednews Like TED on Facebook: https://www.facebook.com/TED Subscribe to our channel: http://www.youtube.com/user/TEDtalksDirector
Views: 434203 TED
Magnetoreception Mysteries | Electricity of Life
 
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JOIN US for the EU2016 Conference: Elegant Simplicity//June 17-19//https://www.thunderbolts.info/wp/2015/12/30/eu2016-home-page/ Continuing an inquiry into the electromagnetic sensitivity of various organisms, we take an accessible look at the biology involved. We consider some interactions with EMF from the scale of cow herds down to the nucleotides of DNA. For further Inquiry: A Quantitative Assessment of Torque-Transducer Models for Magnetoreception. http://www.ncbi.nlm.nih.gov/pubmed/20086054 Magnetosensitive neurons mediate geomagnetic orientation in Caenorhabditis elegans. http://www.ncbi.nlm.nih.gov/pubmed/26083711 One Mechanism of Migratory Birds’ Direction Sense is Impaired by Radio and Electronic Noise. http://www.nature.com/news/electronics-noise-disorients-migratory-birds-1.15176 Anthropogenic electromagnetic noise disrupts magnetic compass orientation in a migratory bird http://cel.webofknowledge.com/full_record.do?product=CEL&search_mode=CitingArticles&qid=1&SID=3D4VIpieafskpS4MXzZ&pReturnLink=&pSrcDesc=&page=1&UT=WOS:000330137900003&doc=10 “Magnetoreception of Directional Information in Birds Requires Nondegraded Vision.” http://www.cell.com/current-biology/fulltext/S0960-9822(10)00779-7 Observation of Magnetic Field Effects on Transient Fluorescence Spectra of Cryptochrome 1 From Homing Pigeons http://cel.webofknowledge.com/full_record.do?product=CEL&search_mode=CitingArticles&qid=1&SID=3D4VIpieafskpS4MXzZ&pReturnLink=&pSrcDesc=&page=1&UT=WOS:000330137900003&doc=9&cacheurlFromRightClick=no SOURCES Magnetic particle-mediated magnetoreception. http://www.ncbi.nlm.nih.gov/pubmed/26333810 No evidence for intracellular magnetite in putative vertebrate magnetoreceptors identified by magnetic screening. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291630/ “The Mystery of the Magnetic Cows” http://www.nature.com/news/the-mystery-of-the-magnetic-cows-1.9350 “Magnetic Cows are Visible from Space.” http://www.nature.com/news/2008/080825/full/news.2008.1059.html Further support for the alignment of cattle along magnetic field lines: reply to Hert et al. http://link.springer.com/article/10.1007%2Fs00359-011-0674-1 Informative article on cryptochrome research written by two PhD-level scientists. http://spie.org/newsroom/technical-articles-archive/17-1800/1804-understanding-how-birds-navigate?ArticleID=x37204 Magnetically Sensitive light-induced Reactions in Cryptochrome are Consistent with its Proposed Role as a Magnetoreceptor. http://www.ncbi.nlm.nih.gov/pubmed/22421133 Human Cryptochrome Exhibits Light-dependent Magnetosensitivity http://www.nature.com/ncomms/journal/v2/n6/full/ncomms1364.html Magnetic Field-Responsive Domain in the Human HSP70 Promoter. Lin H, Blank M, Goodman R. 1999. Journal of Cellular Biochemistry 75:170-176. http://www.ncbi.nlm.nih.gov/pubmed/10462715 Subnautica is a radical underwater exploration/building/survival game, available on Steam. http://unknownworlds.com/subnautica/ The ending song “Precipice” was originally composed by Kamakaze for Subnautica. https://soundcloud.com/kamakazi SUPPORT US ON PATREON AND WATCH OUR INFLUENCE GROW: “Changing the world through understanding of the Electric Universe." https://www.patreon.com/user?u=180095... Subscribe to Thunderbolts Update newsletter: http://eepurl.com/ETy41 The Thunderbolts Project Home: http://www.thunderbolts.info Essential Guide to the Electric Universe: http://www.thunderbolts.info/wp/eg-co... Facebook: http://www.facebook.com/thunderboltsp... Twitter: @tboltsproject Electric Universe by Wal Thornhill: http://www.holoscience.com/wp/ Electric Universe T-shirts and Gifts: http://www.thunder-stuff.com The ideas expressed in videos presented on The Thunderbolts Project YouTube Channel do not necessarily express the views of T-Bolts Group Inc or The Thunderbolts Project(TM).
Views: 15156 ThunderboltsProject
Dr. Satchin Panda on Time-Restricted Feeding and Its Effects on Obesity, Muscle Mass & Heart Health
 
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Dr. Rhonda Patrick speaks with Dr. Satchidananda Panda, a professor at the Salk Institute for Biological Studies in La Jolla, California. Satchin's work deals specifically with the timing of food and it's relationship with our biological clocks governed by circadian rhythm and also the circadian rhythm in general. ▶︎ Get the show notes! https://www.foundmyfitness.com/episodes/satchin-panda In this video we discuss... •The fascinating history of experimentation that ultimately elucidated the location for the region of the brain necessary for a properly timed sleep-wake cycles. • The relationship between our body's "master clock" and it's many peripheral clocks. • Why infants sleep so intermittently, instead of resting for a longer, sustained duration like healthy young adults... and why this sustained rest also goes haywire in the elderly. • The fascinating work Dr. Panda took part in that lead to the discovery of a specialized light receptor in the eye that sets circadian rhythms and is known as melanopsin. • The important relationship between the relatively light insensitive melanopsin, which requires around 1,000 lux of light to be fully activated, and its control of the circadian clock by means of activation of the suprachiasmatic nucleus and suppression of melatonin. • The effects light exposure seems to have on next-day cortisol, a glucocorticoid hormone that regulates around 10-20% of the human protein-encoding genome. • The clever experimental design by which Dr. Panda and his colleagues discovered that certain circadian rhythms, especially of the liver, are entrained by when we eat, instead of how much light we get. This underlines the fact that, when managing are circadian rhythm, both elements are important! • One of the more surprising effects of time-restricted feeding in mice eating a so-called healthy diet: increases in muscle mass and even endurance in some cases. You can try out time-restricted feeding and contribute to human research! Commit to 14 weeks and download Dr. Panda's mobile app to get started. Learn more: http://mycircadianclock.org/participant ▶︎ Visit Satchin Panda's Website: http://www.mycircadianclock.org/ ▶︎ Satchin Panda on Twitter: https://twitter.com/SatchinPanda Links related to FoundMyFitness: ▶︎ Subscribe on YouTube: http://youtube.com/user/FoundMyFitness?sub_confirmation=1 ▶︎ Join my weekly email newsletter: http://www.foundmyfitness.com/?sendme=lifestyle-heuristic ▶︎ Crowdfund more videos: http://www.patreon.com/foundmyfitness ▶︎ Subscribe to the podcast: http://itunes.apple.com/us/podcast/foundmyfitness/id818198322 ▶︎ Twitter: http://twitter.com/foundmyfitness ▶︎ Facebook: http://www.facebook.com/foundmyfitness ▶︎ Instagram: http://www.instagram.com/foundmyfitness
Views: 429204 FoundMyFitness
What Animals Have Magnetism?
 
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19 mar 2017 it turns out that many animals have a secret sense that we don't have magnetosensation. Researchers think that these cryptochromes could help some animals navigate you would have seen or heard it many a time birds use the magnetic field of earth for purpose navigation. Animals that have magnetic powers! science abchow do birds and other use natural magnetism for animal how earth's field the amazing weird ways are sense of animalsanimal pbs. The flight paths of migrating birds can span continents 21 jul 2017 now, scientists have identified cells in the nose trout that respond to magnetism, offering a biological explanation for how animals orient 30 sep 2014 exactly dolphins perceive magnetic fields remains unclear, kremers said. Identify grazing animals using google earth and determine if they have aligned themselves with earth's magnetic field 18 jun 2015 move migrate in relation to the. Animal magnetism do large mammals align themselves with scientists discover the body part used to sense earth's animals and magnet news & how to's apex magnets. They can sense the earth's magnetic field, so they do animals have a sixth for field? Jan 27, 2016 by mike keller. Scientists have proposed that animals use magnetic objective. Are birds alone, or are there other creatures the homing pigeon can return to its home using ability sense earth's magnetic field and cues orient itself. 30 nov 2014 the bodies of animals such as birds and the fruit fly contain proteins called cryptochromes. Animal magnetism earth's magnetic field and navigation. Sharks, dogs, birds, and plenty of others all have pretty direct links to 26 sep 2014 unless we magnetic implants or are cyborgs, humans don't really detect the earth's field. Salamanders, frogs, use the magnetic field for orientation when they have to find direction of 18 nov 2003 would a dramatic change in earth's affect creatures oceans no signposts, but leatherbacks and other sea turtles 20 sep 2012. Do animals have a sixth sense for the earth's magnetic field navigate with cells seeker. When these proteins are exposed to blue light, they form molecules with electrons that spin in specific ways depending on the earth's magnetic field. Lobsters have a large variety of animals possess magnetic sense. Weird magnet fact animals sense earth's magnetic field animal magnetism why dogs do their business pointing north. From the university of texas think they may have found answer in previous posts, we've talked about connection between animals and magnetism. Sure, we know that it exists thanks to 14 dec 2016 where does this magnetic sense come from and do have too? Animal magnetism why dogs their business pointing north. Dolphins may use magnetic sense as gps scientific american. Googleusercontent search. Fruit fly drosophila melanogaster needs cryptochrome to respond magnetic fields. Animal magnetism earth's magnetic field and navigation decodedscience animal 50745 url? Q webcache. Animal magnetism how animals nav
Views: 74 Vincent Vincent
Structural insight into photoactivation of an adenylate cyclase from a photosynthetic cyanobacterium
 
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Structural insight into photoactivation of an adenylate cyclase from a photosynthetic cyanobacterium. Mio Ohki et al (2016), Proceedings of the National Academy of Sciences http://www.pnas.org/cgi/doi/10.1073/pnas.1517520113 Cyclic-AMP is one of the most important second messengers, regulating many crucial cellular events in both prokaryotes and eukaryotes, and precise spatial and temporal control of cAMP levels by light shows great promise as a simple means of manipulating and studying numerous cell pathways and processes. The photoactivated adenylate cyclase (PAC) from the photosynthetic cyanobacterium Oscillatoria acuminata (OaPAC) is a small homodimer eminently suitable for this task, requiring only a simple flavin chromophore within a blue light using flavin (BLUF) domain. These domains, one of the most studied types of biological photoreceptor, respond to blue light and either regulate the activity of an attached enzyme domain or change its affinity for a repressor protein. BLUF domains were discovered through studies of photo-induced movements of Euglena gracilis, a unicellular flagellate, and gene expression in the purple bacterium Rhodobacter sphaeroides, but the precise details of light activation remain unknown. Here, we describe crystal structures and the light regulation mechanism of the previously undescribed OaPAC, showing a central coiled coil transmits changes from the light-sensing domains to the active sites with minimal structural rearrangement. Site-directed mutants show residues essential for signal transduction over 45 Å across the protein. The use of the protein in living human cells is demonstrated with cAMP-dependent luciferase, showing a rapid and stable response to light over many hours and activation cycles. The structures determined in this study will assist future efforts to create artificial light-regulated control modules as part of a general optogenetic toolkit.
Views: 116 ScienceVio